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Defense against infections

Last update 1-11-2008


Glossary of terms
Term Explanation
B-cells B-cells are lymphocytes that develop and mature in the bone marrow to prepare them for their specialized task of antibody production.
Colonization resistance The resistance to colonization of the alimentary canal by newly ingested microorganisms
Eukaryotes Eukaryotes are distinguished from prokaryotes by the structural complexity of the cells - characterized by having many functions segregated into semi-autonomous regions of the cells (organelles), and by the cytoskeleton.
IgA text needed
in sIgA form the IgA molecule is bound to a secretory-piece, a molecule that helps the IgA to migrate across the mucosa.
Innate immunesystem The defense mechanism that works trough binding, fagocytosis and killing, for example by macrophages
PAMP - pathogen associated molecular pattern Recognition of pathogens on the basis of ''pathogen-associated molecular patterns" (PAMPs) by PRRs results in the activation of various types of innate immune responses and often represents a direct induction of effector functions.
PAM - pathogen associated molecule Molecules that aid the fagocytosis cells - such as macrophages - in attaching themselves (binding) to invading bacteria. They 'fit' to molecules on the outer wall of bacteria and are thereby specific to a group of bacteria. The pathogen associated molecules are also called ligand molecules.
phagocytosis Attachment, engulfing and killing and digestion of microorganisms that entered the tissues
PRR - pathogen recognition receptor PRRs are strategically expressed on cells that are the first to encounter pathogens during infection, such as surface epithelia, and also on all types of effector cells of the innate immune system.
T-cells T-cells are lymphocytes that mature in the thymus to become either T-helper cells, T-suppressor cells or cytoxic T-cells and are part of the adaptive immune system.