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Defense against infections

Last update 1-11-2008

Scenario 1 - a mildly spoiled meal


This scenario describes what happens if a more than average number of potential pathogen microorganisms enters the gastro-intestinal tract through mildly spoiled food and is controlled there by colonziation resistance effects.

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The defense against infections: scenario 1 - a mildly spoiled meal
eating a mildly spoiled meal phase 1 eating a mildly spoiled meal phase 2 eating a mildly spoiled meal phase 3
A mildly spoiled meal contains more than average potential pathogens Once in the mouth these potential pathogens are soon covered in IgA or killed by defensins.
Some survive by being inside a food particle or by being transported rapidly by a gulp of liquid
Once in the gut more defensins kill off more potential pathogen microorganisms, while the colonization resistance factors ensure no potential pathogen microorganism can reach the gut wall and attach to it. Gut peristalsis ensures the remaining potential pathogen microorganisms are moved towards the end of the gut.
eating a mildly spoiled meal phase 4 eating a mildly spoiled meal phase 5  
The potential pathogen microorganisms have been moved to the gut lumen by peristaltic movement and are kept in the gut lumen by other microorganisms, a significant part of which belong to the autochtonous microflora, through crowding the gut wall. This blocks the potential pathogen microorganisms from attaching to the gut wall. Those few that do reach the gut wall are either blocked from firmly attaching to it by blocking factors for adherence or by epithelial cells that form the gut wall and that are shedded into the lumen after a few days. Unable to attach themselves to the gut wall the potential pathogen microorganisms are expelled from the gut harmlessly.