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Defense against infections

Last update 1-11-2008

Scenario 2 - a spoiled meal


This scenario describes what happens if a large number of potentially pathogenic microorganisms enters the gastro-intestinal tract through spoiled food and is controlled there by colonziation resistance effects combined with with elements of the ideotypic immune system.

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The defense against infections: scenario 2 - a spoiled meal
eating a spoiled meal phase 1 eating a spoiled meal phase 2 eating a spoiled meal phase 3
A spoiled meal contains large numbers of potential pathogens Once in the mouth these potential pathogens are soon covered in IgA or killed by defensins.
Many survive by being inside a food particle or by being transported rapidly by a gulp of liquid
Once in the gut more defensins kill off more potential pathogen microorganisms, while the colonization resistance factors ensure most potential pathogen microorganism can reach the gut wall and attach to it. Some however manage to attach themselves to the gut wall by overwhelming the existing occupants by sheer numbers.
Gut peristalsis ensures most of the potential pathogen microorganisms are moved towards the end of the gut.
eating a spoiled meal phase 4 eating a spoiled meal phase 5  
The potential pathogen microorganisms have been moved to the gut lumen by peristaltic movement and although most are kept in the gut lumen by other microorganisms, some manage to attach themselves to the gut wall and wriggle through it (translocate). Translocated microorganisms are ingested by leukocytes and processed to provide antigenic information to host immune cells for a specific immune response.
Gut peristaltic movements ensure most, unattached, potential pathogen microorganisms are moved onward towards the end of the gut, ensuring the attack on the gut wall is temporary.
Unable to attach themselves to the gut wall the potential pathogen microorganisms are expelled from the gut harmlessly. Those that did manage to attach themselves and even translocate are quickly killed by white blood cells, such as phagocytes and granulocytes, through phagocytosis.