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Defense against infections

Last update 1-11-2008

Scenario 3 - a severely spoiled meal


This scenario describes what happens if a huge number of potential pathogen microorganisms enters the gastro-intestinal tract through spoiled food and is barely controlled by the combined defensive mechanisms.

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The defense against infections: scenario 3 - a severely spoiled meal
eating a severely spoiled meal phase 1 eating a severely spoiled meal phase 2 eating a severely spoiled meal phase 3
A severely spoiled meal contains very large numbers of potential pathogens Once in the mouth many of these potential pathogens are soon covered in IgA or killed by defensins.
Very many survive by being inside a food particle or by being transported rapidly by a gulp of liquid
Once in the gut more defensins, which are produced in much increased volume, kill off more (potential) pathogen microorganisms. The potential pathogen microorganisms are in such numbers that they overwhelm the colonization resistance factors so very many can reach the gut wall and attach to it. Many also mange to translocate through the gut wall. These are captured by macrophages (??) in the Gut Associated Lymphoid Tissue
Gut peristalsis ensures most of the potential pathogen microorganisms are moved towards the end of the gut.
eating a severely spoiled meal phase 4 eating a severely spoiled meal phase 5  
As the potential pathogen microorganisms have been moved to the gut lumen by peristaltic movement ?? STORY ABOUT B-CELLS AND T-CELLS?
Gut peristaltic movements ensure most, unattached, potential pathogen microorganisms are moved onward towards the end of the gut, ensuring the attack on the gut wall is temporary.
Unable to attach themselves to the gut wall most potential pathogen microorganisms are expelled from the gut harmlessly. Those that did manage to attach themselves and even translocate are quickly killed by MACROPHAGES??